Recent Publications

2017

Yellow Fever Virus, but Not Zika Virus or Dengue Virus, Inhibits T-Cell Receptor-Mediated T-Cell Function by an RNA-Based Mechanism.
McLinden JH, Bhattarai N, Stapleton JT, Chang Q, Kaufman TM, Cassel SL, Sutterwala FS, Haim H, Houtman JC, Xiang J.
J Infect Dis. 2017 Nov 27;216(9):1164-1175. doi: 10.1093/infdis/jix462.
PMID: 28968905

 

Combination Adenovirus and Protein Vaccines Prevent Infection or Reduce Viral Burden after Heterologous Clade C SHIV Mucosal Challenge.
Malherbe DC, Mendy J, Vang L, Barnette PT, Reed J, Lakhashe SK, Owuor J, Gach JS, Legasse AW, Axthelm MK, LaBranche CC, Montefiori D, Forthal DN, Park B, Wilson JM, McLinden JH, Xiang J, Stapleton JT, Sacha JB, Haynes BF, Liao HX, Ruprecht RM, Smith J, Gurwith M, Haigwood NL, Alexander J.
J Virol. 2017 Nov 1. pii: JVI.01092-17. doi: 10.1128/JVI.01092-17. [Epub ahead of print]
PMID: 29093095

 

FcRL4 Expression Identifies a Pro-inflammatory B Cell Subset in Viremic HIV-Infected Subjects.
Siewe B, Nipper AJ, Sohn H, Stapleton JT, Landay A.
Front Immunol. 2017 Oct 20;8:1339. doi: 10.3389/fimmu.2017.01339. eCollection 2017.
PMID: 29104574

 

Src-family kinases negatively regulate NFAT signaling in resting human T cells.
Baer A, Colon-Moran W, Xiang J, Stapleton JT, Bhattarai N.
PLoS One. 2017 Oct 26;12(10):e0187123. doi: 10.1371/journal.pone.0187123. eCollection 2017.
PMID: 29073235 

 

Yellow fever virus, but not Zika or Dengue virus inhibits T cell receptor-mediated T cell function by an RNA-based mechanism.
McLinden JH, Bhattarai N, Stapleton JT, Chang Q, Kaufman TM, Cassel SL, Sutterwala FS, Haim H, Houtman J, Xiang J.
J Infect Dis. 2017 Sep 2. doi: 10.1093/infdis/jix462. [Epub ahead of print]
PMID: 28968905

 

Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae.
Smith DB, Meyers G, Bukh J, Gould EA, Monath T, Scott Muerhoff A, Pletnev A, Rico-Hesse R, Stapleton JT, Simmonds P, Becher P.
J Gen Virol. 2017 Aug 8. doi: 10.1099/jgv.0.000873. [Epub ahead of print]
PMID: 28786787

 

Tularemia vaccine: Safety, reactogenicity, "Take" skin reactions, and antibody responses following vaccination with a new lot of the Francisella tularensis live vaccine strain - A phase 2 randomized clinical Trial. Mulligan MJ, Stapleton JT, Keitel WA, Frey SE, Chen WH, Rouphael N, Edupuganti S, Beck A, Winokur PL, El Sahly HM, Patel SM, Atmar RL, Graham I, Anderson E, El-Kamary SS, Pasetti MF, Sztein MB, Hill H, Goll JB; DMID 08-0006 Tularemia Vaccine Study Group.
Vaccine. 2017 Aug 24;35(36):4730-4737. doi: 10.1016/j.vaccine.2017.07.024. Epub 2017 Jul 24.
PMID: 28750854

 

Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model.
DeLeon O, Hodis H, O'Malley Y, Johnson J, Salimi H, Zhai Y, Winter E, Remec C, Eichelberger N, Van Cleave B, Puliadi R, Harrington RD, Stapleton JT, Haim H.
PLoS Biol. 2017 Apr 6;15(4):e2001549. doi: 10.1371/journal.pbio.2001549. eCollection 2017 Apr.
PMID: 28384158 

 

Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo.
Bhattarai N, McLinden JH, Xiang J, Mathahs MM, Schmidt WN, Kaufman TM, Stapleton JT.
PLoS Pathog. 2017 Feb 24;13(2):e1006232. doi: 10.1371/journal.ppat.1006232. eCollection 2017 Feb.
PMID: 28235043 

 

ICTV Virus Taxonomy Profile: Flaviviridae.
Simmonds P, Becher P, Bukh J, Gould EA, Meyers G, Monath T, Muerhoff S, Pletnev A, Rico-Hesse R, Smith DB, Stapleton JT, Ictv Report Consortium.
J Gen Virol. 2017 Jan;98(1):2-3. doi: 10.1099/jgv.0.000672.
PMID: 28218572


2016

Hepatitis Viruses in Kidney Transplantation.
Gajurel K, Stapleton JT.
Semin Nephrol. 2016 Sep;36(5):386-396. doi: 10.1016/j.semnephrol.2016.05.015. Review.
PMID: 27772623

 

Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family.
Smith DB, Becher P, Bukh J, Gould EA, Meyers G, Monath T, Muerhoff AS, Pletnev A, Rico-Hesse R, Stapleton JT, Simmonds P.
J Gen Virol. 2016 Nov;97(11):2894-2907. doi: 10.1099/jgv.0.000612. Epub 2016 Sep 28.
PMID: 27692039

 

Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 7-year follow-up of the phase 3, double-blind, randomised controlled VIVIANE study.
Wheeler CM, Skinner SR, Del Rosario-Raymundo MR, Garland SM, Chatterjee A, Lazcano-Ponce E, Salmerón J, McNeil S, Stapleton JT, Bouchard C, Martens MG, Money DM, Quek SC, Romanowski B, Vallejos CS, Ter Harmsel B, Prilepskaya V, Fong KL, Kitchener H, Minkina G, Lim YK, Stoney T, Chakhtoura N, Cruickshank ME, Savicheva A, da Silva DP, Ferguson M, Molijn AC, Quint WG, Hardt K, Descamps D, Suryakiran PV, Karkada N, Geeraerts B, Dubin G, Struyf F; VIVIANE Study Group..
Lancet Infect Dis. 2016 Oct;16(10):1154-68. doi: 10.1016/S1473-3099(16)30120-7. Epub 2016 Jun 28.
PMID: 27373900

 

A Randomized, Double-Blind, Placebo-Controlled Phase II Trial Investigating the Safety and Immunogenicity of Modified Vaccinia Ankara Smallpox Vaccine (MVA-BN®) in 56-80-Year-Old Subjects.
Greenberg RN, Hay CM, Stapleton JT, Marbury TC, Wagner E, Kreitmeir E, Röesch S, von Krempelhuber A, Young P, Nichols R, Meyer TP, Schmidt D, Weigl J, Virgin G, Arndtz-Wiedemann N, Chaplin P.
PLoS One. 2016 Jun 21;11(6):e0157335. doi: 10.1371/journal.pone.0157335. eCollection 2016.
PMID: 27327616 

 

A sequential classification rule based on multiple quantitative tests in the absence of a gold standard.
Zhang J, Zhang Y, Chaloner K, Stapleton JT.
Stat Med. 2016 Apr 15;35(8):1359-72. doi: 10.1002/sim.6780. Epub 2015 Nov 2.
PMID: 26522690


2015

Ethnicity and Smoking-Associated DNA Methylation Changes at HIV Co-Receptor GPR15.
Dogan MV, Xiang J, Beach SR, Cutrona C, Gibbons FX, Simons RL, Brody GH, Stapleton JT, Philibert RA.
Front Psychiatry. 2015 Sep 22;6:132. doi: 10.3389/fpsyt.2015.00132. eCollection 2015.
PMID: 26441693 

 

Conserved Motifs within Hepatitis C Virus Envelope (E2) RNA and Protein Independently Inhibit T Cell Activation.
Bhattarai N, McLinden JH, Xiang J, Kaufman TM, Stapleton JT.
PLoS Pathog. 2015 Sep 30;11(9):e1005183. doi: 10.1371/journal.ppat.1005183. eCollection 2015 Sep.
PMID: 26421924 

 

Human Pegivirus (HPgV; formerly known as GBV-C) inhibits IL-12 dependent natural killer cell function.
Chivero ET, Bhattarai N, McLinden JH, Xiang J, Stapleton JT.
Virology. 2015 Nov;485:116-27. doi: 10.1016/j.virol.2015.07.008. Epub 2015 Aug 1.
PMID: 26245365 

 

Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naïve subjects.
Frey SE, Wald A, Edupuganti S, Jackson LA, Stapleton JT, El Sahly H, El-Kamary SS, Edwards K, Keyserling H, Winokur P, Keitel W, Hill H, Goll JB, Anderson EL, Graham IL, Johnston C, Mulligan M, Rouphael N, Atmar R, Patel S, Chen W, Kotloff K, Creech CB, Chaplin P, Belshe RB.
Vaccine. 2015 Sep 22;33(39):5225-34. doi: 10.1016/j.vaccine.2015.06.075. Epub 2015 Jul 2.
PMID: 26143613

 

Hepatitis C Management and the Infectious Diseases Physician: A Survey of Current and Anticipated Practice Patterns.
Chastain CA, Beekmann SE, Wallender EK, Hulgan T, Stapleton JT, Polgreen PM.
Clin Infect Dis. 2015 Sep 1;61(5):792-4. doi: 10.1093/cid/civ384. Epub 2015 May 15.
PMID: 25979310

 

Tropism of human pegivirus (formerly known as GB virus C/hepatitis G virus) and host immunomodulation: insights into a highly successful viral infection.
Chivero ET, Stapleton JT.
J Gen Virol. 2015 Jul;96(Pt 7):1521-32. doi: 10.1099/vir.0.000086. Epub 2015 Feb 9. Review.
PMID: 25667328

 

Downregulation of Cytokines and Chemokines by GB Virus C After Transmission Via Blood Transfusion in HIV-Positive Blood Recipients.
Lanteri MC, Vahidnia F, Tan S, Stapleton JT, Norris PJ, Heitman J, Deng X, Keating SM, Brambilla D, Busch MP, Custer B; NHLBI REDS III Study..
J Infect Dis. 2015 May 15;211(10):1585-96. doi: 10.1093/infdis/jiu660. Epub 2014 Nov 25.
PMID: 25425697 

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